Yasmin 21 Day (Yasmin 21 Day)3/0.03mg

Frequency not defined. Reactions listed are based on reports for other agents in this same pharmacologic class (oral contraceptives) and may not be specifically reported for drospirenone/ethinyl estradiol.

Increased risk or evidence of association with use:

Cardiovascular: Arterial thromboembolism, cerebral thrombosis, hypertension, local thrombophlebitis, mesenteric thrombosis, myocardial infarction, pulmonary embolism, retinal thrombosis

Central nervous system: Cerebral hemorrhage

Gastrointestinal: Gallbladder disease

Hepatic: Hepatic adenoma, hepatic neoplasm (benign)

Adverse reactions considered drug related:

Cardiovascular: Edema, worsening of varicose veins

Central nervous system: Depression, exacerbation of tics, migraine

Dermatologic: Allergic skin rash, chloasma

Endocrine & metabolic: Amenorrhea, breast changes (breast hypertrophy, breast secretion, breast tenderness, mastalgia), decreased serum folate level, exacerbation of porphyria, menstrual disease (menstrual flow changes), weight changes

Gastrointestinal: Abdominal cramps, bloating, carbohydrate intolerance, nausea, vomiting

Genitourinary: Breakthrough bleeding, cervical ectropion, cervical erosion, change in cervical secretions, decreased lactation (with use immediately postpartum), infertility (temporary), spotting, vulvovaginal candidiasis

Hepatic: Cholestatic jaundice

Hypersensitivity: Anaphylaxis/anaphylactoid reaction (including angioedema, circulatory shock, respiratory collapse, urticaria)

Neuromuscular & skeletal: Exacerbation of systemic lupus erythematosus

Ophthalmic: Change in corneal curvature (steepening), contact lens intolerance

Adverse reactions in which association is not confirmed or denied:

Cardiovascular: Budd-Chiari syndrome

Central nervous system: Dizziness, headache, nervousness

Dermatologic: Acne vulgaris, erythema multiforme, erythema nodosum, loss of scalp hair

Endocrine & metabolic: Change in libido, hirsutism, porphyria, premenstrual syndrome

Gastrointestinal: Change in appetite, colitis, pancreatitis

Genitourinary: Cystitis-like syndrome, dysmenorrhea, vaginitis

Hematologic & oncologic: Hemolytic-uremic syndrome, hemorrhagic eruption

Ophthalmic: Cataract, optic neuritis (with or without partial or complete loss of vision)

Renal: Renal insufficiency