Dilantin (Dilantin)100mg – 100 tablet

Phenytoin Information

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Pronunciation

FEN i toyn

 

What is this drug used for?

– It is used to help control certain kinds of seizures.

– It may be given to you for other reasons. Talk with the doctor.

Frequently reported side effects of this drug

– Fatigue

– Headache

– Anxiety

– Trouble sleeping

– Constipation

– Vomiting

– Change in taste

– Nausea

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

– Infection

– Stevens-Johnson syndrome/toxic epidermal necrolysis like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in mouth, throat, nose, or eyes

– Depression like thoughts of suicide, anxiety, emotional instability, agitation, irritability, panic attacks, mood changes, behavioral changes, or confusion

– High blood sugar like confusion, fatigue, increased thirst, increased hunger, passing a lot of urine, flushing, fast breathing, or breath that smells like fruit

– Change in balance

– Abnormal gait

– Confusion

– Slurred speech

– Gingival pain or swelling

– Severe muscle pain

– Abnormal movements

– Twitching

– Trouble swallowing

– Trouble speaking

– Severe loss of strength and energy

– Seizures

– Burning or numbness feeling

– Bruising

– Bleeding

– Bone pain

– Involuntary eye movements

– Tremors

– Swollen glands

– Fever

– Rash

– Chest pain

– Unable to pass urine

– Change in amount of urine passed

– Liver problems like dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin

– Fast heartbeat

– Slow heartbeat

– Abnormal heartbeat

– Severe dizziness

– Passing out

– Severe injection site redness, swelling, pain, or irritation

– Skin discoloration

– Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

 

Medication Safety Issues

 

Storage and Stability

Capsule, tablet: Store at 20?C to 25?C (68?F to 77?F). Protect capsules from light. Protect capsules and tablets from moisture.

Oral suspension: Store at 20?C to 25?C (68?F to 77?F); do not freeze. Protect from light.

Solution for injection: Store at 15?C to 30?C (59?F to 86?F). Use only clear solutions free of precipitate and haziness; slightly yellow solutions may be used. Precipitation may occur if solution is refrigerated and may dissolve at room temperature. Discard any unused product.

 

Adverse Reactions

Cardiovascular: Cardiac arrhythmia, cardiac conduction disturbance (depression), circulatory shock, hypotension, ventricular fibrillation

Central nervous system: Ataxia, cerebral atrophy (elevated serum levels and/or long-term use), cerebral dysfunction (elevated serum levels and/or long-term use), confusion, dizziness, drowsiness, headache, insomnia, nervousness, paresthesia, peripheral neuropathy (associated with chronic treatment), slurred speech, suicidal ideation, suicidal tendencies, twitching, vertigo

Dermatologic: Bullous dermatitis, exfoliative dermatitis, morbilliform rash, scarlatiniform rash, skin or other tissue necrosis, skin rash

Endocrine & metabolic: Decreased T4, increased gamma-glutamyl transferase, vitamin D deficiency (associated with chronic treatment)

Gastrointestinal: Constipation, dysgeusia, gingival hyperplasia, nausea, swelling of lips, vomiting

Genitourinary: Peyronie’s disease

Hematologic & oncologic: Macrocytosis, megaloblastic anemia, pseudolymphoma, purpuric dermatitis

Hepatic: Acute hepatic failure, hepatic injury, hepatitis, increased serum alkaline phosphatase, toxic hepatitis

Local: Injection site reaction (“purple glove syndrome;” edema, discoloration, and pain distal to injection site), local inflammation, local irritation, localized tenderness, local tissue necrosis

Neuromuscular & skeletal: Osteomalacia

Ophthalmic: Nystagmus

Miscellaneous: Fever, tissue sloughing