Medication Safety Issues
Sound-alike/look-alike issues:
Yaz may be confused with Beyaz, Yasmin
Storage/Stability
Store at 25?C (77?F); excursions permitted to 15?C to 30?C (59?F to 86?F).
Adverse Reactions
Frequency not defined. Reactions listed are based on reports for other agents in this same pharmacologic class (oral contraceptives) and may not be specifically reported for drospirenone/ethinyl estradiol.
Increased risk or evidence of association with use:
Cardiovascular: Arterial thromboembolism, cerebral thrombosis, hypertension, local thrombophlebitis, mesenteric thrombosis, myocardial infarction, pulmonary embolism, retinal thrombosis
Central nervous system: Cerebral hemorrhage
Gastrointestinal: Gallbladder disease
Hepatic: Hepatic adenoma, hepatic neoplasm (benign)
Adverse reactions considered drug related:
Cardiovascular: Edema, worsening of varicose veins
Central nervous system: Depression, exacerbation of tics, migraine
Dermatologic: Allergic skin rash, chloasma
Endocrine & metabolic: Amenorrhea, breast changes (breast hypertrophy, breast secretion, breast tenderness, mastalgia), decreased serum folate level, exacerbation of porphyria, menstrual disease (menstrual flow changes), weight changes
Gastrointestinal: Abdominal cramps, bloating, carbohydrate intolerance, nausea, vomiting
Genitourinary: Breakthrough bleeding, cervical ectropion, cervical erosion, change in cervical secretions, decreased lactation (with use immediately postpartum), infertility (temporary), spotting, vulvovaginal candidiasis
Hepatic: Cholestatic jaundice
Hypersensitivity: Anaphylaxis/anaphylactoid reaction (including angioedema, circulatory shock, respiratory collapse, urticaria)
Neuromuscular & skeletal: Exacerbation of systemic lupus erythematosus
Ophthalmic: Change in corneal curvature (steepening), contact lens intolerance
Adverse reactions in which association is not confirmed or denied:
Cardiovascular: Budd-Chiari syndrome
Central nervous system: Dizziness, headache, nervousness
Dermatologic: Acne vulgaris, erythema multiforme, erythema nodosum, loss of scalp hair
Endocrine & metabolic: Change in libido, hirsutism, porphyria, premenstrual syndrome
Gastrointestinal: Change in appetite, colitis, pancreatitis
Genitourinary: Cystitis-like syndrome, dysmenorrhea, vaginitis
Hematologic & oncologic: Hemolytic-uremic syndrome, hemorrhagic eruption
Ophthalmic: Cataract, optic neuritis (with or without partial or complete loss of vision)
Renal: Renal insufficiency
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